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| Product Name: |
phenibut
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| Supply Ability: |
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| Related proudcts |
4-amino-3-phenylbuty, 4-amino-3-phenylbuty, |
| Specifications |
25Kg fiber drum/carton .Packing as the need of customer |
| Price Term: |
fob |
| Port of loading: |
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| Minimum Order |
100kg |
| Unit Price: |
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Phenibut is a derivative of the neurotransmitter GABA that crosses the blood-brain barrier. It was developed in Russia, and there it has been used clinically since the 1960's for a range of purposes. Phenibut has both nootropic and anxiolytic (anxiety-reducing) properties, and it is commonly co***red to diazepam (Valium), baclofen, and piracetam, and it has similarities to and differences from all of these substances.
FUNCTION:
Structurally, phenibut is similar to GABA, baclofen (p-Cl-phenibut), and beta-phenylethylamine (PEA). GABA is the primary inhibitory neurotransmitter in the brain. The addition of the phenyl ring to GABA allows the compound to more easily cross the blood-brain barrier, but also changes its activity profile. Baclofen is a drug commonly used in studies on GABA(B) receptors, and also clinically used to treat severe ***sticity of cerebral origin. PEA is a naturally occuring biogenic amine which is similar in structure to amphetamine, and like amphetamine, it is a stimulant that causes the release of dopamine, and also promotes anxiety in high enough amounts.
Phenibut is a GABA receptor agonist and also causes the release of GABA. Similar to baclofen, phenibut is an agonist at GABA(B) receptors, although it does have some effect on GABA(A) receptors as well. It is possible that phenibut has a higher activity at central GABA(B) receptors than peripheral ones. The role of the GABA(B) receptor is not well-established, although research in the last seven years has significantly increased our understanding of this receptor. The most well-established role of GABA(B) receptors is inhibition of the release of some neurotransmitters, and it may also serve as a negative feedback mechanism for GABA release
Because of the structural similarity to PEA, phenibut may share some similarities and differences with it. When phenibut is administered along with PEA, it antagonizes many of its effects, such as promotion of anxiety, promotion of seizures, and hyperthermia. This has lead some to postulat |
| Company: |
waseta
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| Contact: |
Ms. zou duolin |
| Address: |
room 2001-2002 ,golden eagle edifice b ,no.1518 minsheng rode,pudong new area |
| Postcode: |
200135 |
| Tel: |
86 21 61049360 |
| Fax: |
86 21 61049330 |
| E-mail: |
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